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Articles

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  1. Karyotype 46, XY female disorders of sex development (46, XY female DSD) are congenital conditions due to irregular gonadal development or androgen synthesis or function issues. Genes significantly influence D...

    Authors: Chunlin Wang, Hong Chen, Qingqing Chen, Yangbin Qu, Ke Yuan, Li Liang and Qingfeng Yan
    Citation: Biological Research 2025 58:1
  2. Breast cancer is a leading cause of cancer-related mortality worldwide, with hereditary forms accounting for approximately 10% of cases. In Chile, significant gaps exist in genetic counseling and testing, part...

    Authors: Natalia Landeros, Laura Vargas-Roig, Silvina Denita, Alejandra Mampel, Rafael Hasbún, Hernán Araya, Iván Castillo, Camila Valdes, Marcela Flores, Juan Salgado Salter, Katherin Vasquez, Jacqueline Romero and Ramón Pérez-Castro
    Citation: Biological Research 2024 57:99
  3. NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at the cellular surface. In cancer, these highly reactive molecules primarily originate in...

    Authors: Nelson Quilaqueo-Millaqueo, David A. Brown-Brown, Jetzabel A. Vidal-Vidal and Ignacio Niechi
    Citation: Biological Research 2024 57:98
  4. Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichan...

    Authors: Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez and Alejandro S. Godoy
    Citation: Biological Research 2024 57:97
  5. Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, ...

    Authors: Cristóbal Vacarezza, Julieta Araneda, Pamela Gonzalez, Oscar Arteaga, Katherine Marcelain, Enrique A. Castellon, Ana Periera, Maroun Khoury, Bettina Müller, Juan Alberto Lecaros, Sofia P. Salas, Arnoldo Riquelme, Alejandro H. Corvalan, Jorge Jiménez de la Jara, Catterina Ferreccio, Carolina Goic…
    Citation: Biological Research 2024 57:95
  6. Assam's aromatic Joha rice is a unique rice class famous for its aroma, taste, and nutritional benefits, which fetch high market prices in domestic and international markets. Joha landraces are inherently poor yi...

    Authors: Bodeddula Jayasankar Reddy, Shreekant M. Baradkar, Tamma V. S. S. Manogna, Dibosh Bordoloi, Subhash C. Bihani, Nagendra Sarma Barua, Akhil Ranjan Baruah, Bikram Kishore Das, Suvendu Mondal and Debojit Sarma
    Citation: Biological Research 2024 57:94
  7. The human neocortex has a huge surface area with unique cytoarchitectonics, most of which is concealed in sulci. Some cytoarchitectonic fields are associated with macroscopic landmarks. In particular, the prim...

    Authors: Olga Godovalova, Alexandra Proshchina, Anastasia Kharlamova, Valeriy Barabanov, Yuliya Krivova, Olga Junemann, Marina Shahina and Sergey Saveliev
    Citation: Biological Research 2024 57:93
  8. The Western honey bee, Apis mellifera, is an economically important pollinator, as well as a tractable species for studying the behavioral intricacies of eusociality. Honey bees are currently being challenged by ...

    Authors: Jordan Twombly Ellis and Juliana Rangel
    Citation: Biological Research 2024 57:92
  9. The activity of perivascular adipose tissue (PVAT), a specific deposit of adipose tissue surrounding blood vessels, could contribute to sex differences in vascular tone control, particularly in dyslipidemic di...

    Authors: Sona Cacanyiova, Andrea Berenyiova, Hana Malinska, Martina Huttl, Irena Markova, Basak G. Aydemir, Veronika Garaiova and Martina Cebova
    Citation: Biological Research 2024 57:91
  10. The establishment of apicobasal polarity in epithelial cells is of critical importance in morphogenesis of mammary gland and other secretive gland tissues. The demise of the polarity is a critical step in earl...

    Authors: Huan-Yu Zhao, Yi-Pan Zhu, Ying Wen, Jing Sun, Xin-Yu Ding, Xin-Yu Cao, Kai-Liang Wu, Li Fu and Lu-Yuan Li
    Citation: Biological Research 2024 57:90
  11. Induced neural stem cells (iNSCs), which have similar properties to neural stem cells and are able to self-proliferate and differentiate into neural cell lineages, are expected to be potential cells for the tr...

    Authors: Qiongqiong Ji, Yuanhao Lv, Bei Hu, Yue Su, Imran Ibrahim Shaikh and Xu Zhu
    Citation: Biological Research 2024 57:89
  12. Outstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude hypobaric-hypoxia (HH), there is a baroreflex-dependent parasympathetic withdrawal and...

    Authors: Camila Salazar-Ardiles, Carlos Cornejo, Cristobal Paz, Manuel Vasquez-Muñoz, Alexis Arce-Alvarez, Maria Rodriguez-Fernandez, Gregoire P. Millet, Mikel Izquierdo and David C. Andrade
    Citation: Biological Research 2024 57:88
  13. Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing t...

    Authors: Md. Samsuzzaman, Seong-Min Hong, Jae Hyuk Lee, Hyunjun Park, Keun-A Chang, Hyun-Bum Kim, Myoung Gyu Park, Hyeyoon Eo, Myung Sook Oh and Sun Yeou Kim
    Citation: Biological Research 2024 57:87
  14. Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to famili...

    Authors: Luis Labrador, Leonardo Rodriguez, Sebastián Beltran, Fernanda Hernandez, Laura Gomez, Patricia Ojeda, Cristian Bergmann, Melissa Calegaro-Nassif, Bredford Kerr, Danilo B. Medinas, Patricio Manque and Ute Woehlbier
    Citation: Biological Research 2024 57:86
  15. The aberrant expression of placental imprinted genes due to epigenetic alterations during pregnancy can impact fetal development. We investigated the impact of dietary modification of low vitamin B12 with vary...

    Authors: Divika Sapehia, Aatish Mahajan, Parampal Singh and Jyotdeep Kaur
    Citation: Biological Research 2024 57:85
  16. Aquaculture and salmon farming can cause environmental problems due to the pollution of the surrounding waters with nutrients, solid wastes and chemicals, such as antibiotics, which are used for disease contro...

    Authors: Javiera Ortiz-Severín, Christian Hodar, Camila Stuardo, Constanza Aguado-Norese, Felipe Maza, Mauricio González and Verónica Cambiazo
    Citation: Biological Research 2024 57:84
  17. abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female diseases. However, the mechanisms of oocyte meiosis remain largely unknown, especially epi...

    Authors: Ting Jiang, Chengxiu Zhang, Xinjing Cao, Yingpu Tian, Han Cai, Shuangbo Kong, Jinhua Lu, Haibin Wang and Zhongxian Lu
    Citation: Biological Research 2024 57:83
  18. Domestication can be understood as a symbiotic relationship that benefits both domesticator and domesticated species, involving multiple genetic changes that configure the phenotype of the domesticated species...

    Authors: Guilherme Rocha, Melissa Gómez, Camila Baeza, Francisco Salinas, Claudio Martínez and Eduardo I. Kessi-Pérez
    Citation: Biological Research 2024 57:82
  19. During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor (PRR) on the apical plasma membrane triggers intracellular profibrotic genes, includin...

    Authors: Paulina E. Larenas, Pilar Cárdenas, Monserrat Aguirre-Delgadillo, Carlos Moris, Dulce E. Casarini, Zoe Vallotton, Minolfa C. Prieto and Alexis A. Gonzalez
    Citation: Biological Research 2024 57:81
  20. Conventional pre-genomics breeding methodologies have significantly improved crop yields since the mid-twentieth century. Genomics provides breeders with advanced tools for whole-genome study, enabling a direc...

    Authors: Rahul Kumar, Sankar Prasad Das, Burhan Uddin Choudhury, Amit Kumar, Nitish Ranjan Prakash, Ramlakhan Verma, Mridul Chakraborti, Ayam Gangarani Devi, Bijoya Bhattacharjee, Rekha Das, Bapi Das, H. Lembisana Devi, Biswajit Das, Santoshi Rawat and Vinay Kumar Mishra
    Citation: Biological Research 2024 57:80
  21. Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin C/sodium co-transporter SVCT2 is prefere...

    Authors: Daniel Sandoval, Jessica Mella, Jorge Ojeda, Francisca Bermedo-García, Marcela Low, Sylvain Marcellini, Maite A. Castro, Mariana Casas, Enrique Jaimovich and Juan Pablo Henríquez
    Citation: Biological Research 2024 57:79
  22. The yeast Xanthophyllomyces dendrorhous synthesizes astaxanthin, a high-value carotenoid with biotechnological relevance in the nutraceutical and aquaculture industries. However, enhancing carotenoid production t...

    Authors: Alejandro Durán, Maximiliano Venegas, Salvador Barahona, Dionisia Sepúlveda, Marcelo Baeza, Víctor Cifuentes and Jennifer Alcaíno
    Citation: Biological Research 2024 57:78
  23. C3H10T1/2 is a mesenchymal cell line capable of differentiating into osteoblasts, adipocytes and chondrocytes. The differentiation of these cells into osteoblasts is modulated by various transcription factors,...

    Authors: María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Eva-María Monsalve, María-José M. Díaz-Guerra, Moustapha Kassem, Jorge Laborda, María-Luisa Nueda and Victoriano Baladrón
    Citation: Biological Research 2024 57:77
  24. There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory...

    Authors: Henry David Mogollón García, Rodrigo de Andrade Ferrazza, Julian Camilo Ochoa, Flávia Florencio de Athayde, Pedro Marcus Pereira Vidigal, Milo Wiltbank, John Patrick Kastelic, Roberto Sartori and João Carlos Pinheiro Ferreira
    Citation: Biological Research 2024 57:76
  25. Determining the postmortem interval (PMI) accurately remains a significant challenge in forensic sciences, especially for intervals greater than 5 years (late PMI). Traditional methods often fail due to the ex...

    Authors: Camila Garcés-Parra, Pablo Saldivia, Mauricio Hernández, Elena Uribe, Juan Román, Marcela Torrejón, José L. Gutiérrez, Guillermo Cabrera-Vives, María de los Ángeles García-Robles, William Aguilar, Miguel Soto and Estefanía Tarifeño-Saldivia
    Citation: Biological Research 2024 57:75
  26. Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ETAR and its activating enzyme, the endothelin-converting enzyme-1 (ECE-1), have been report...

    Authors: Cristopher Almarza, Karla Villalobos-Nova, María A. Toro, Manuel González, Ignacio Niechi, David A. Brown‑Brown, Rodrigo A. López-Muñoz, Eduardo Silva-Pavez, Belén Gaete-Ramírez, Manuel Varas-Godoy, Verónica A. Burzio, Lilian Jara, Francisco Aguayo and Julio C. Tapia
    Citation: Biological Research 2024 57:74
  27. In vitro embryo production is increasingly used for genetic improvement in cattle but bypasses the oviduct environment and exposes the embryos to oxidative stress with deleterious effects on further developmen...

    Authors: Thanya Pranomphon, Álvaro López-Valiñas, Carmen Almiñana, Coline Mahé, Viviane Lopes Brair, Rangsun Parnpai, Pascal Mermillod, Stefan Bauersachs and Marie Saint-Dizier
    Citation: Biological Research 2024 57:73
  28. Stroke is a leading cause of death worldwide, with oxidative stress and calcium overload playing significant roles in the pathophysiology of the disease. Ozone, renowned for its potent antioxidant properties, ...

    Authors: Jiahui Li, Xiaolei Liu, Zengze Wang, Pengyun Xie, Min Zhu, Hanhui Zhong, Sirui Luo, Jing Tang and Guixi Mo
    Citation: Biological Research 2024 57:71
  29. Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenata...

    Authors: Mario Sánchez-Rubio, Lorena Abarzúa-Catalán, Ana del Valle, Maxs Méndez-Ruette, Natalia Salazar, Jacinta Sigala, Soledad Sandoval, María Inés Godoy, Alejandro Luarte, Lara J. Monteiro, Roberto Romero, Mahesh A. Choolani, Úrsula Wyneken, Sebastián E. Illanes and Luis Federico Bátiz
    Citation: Biological Research 2024 57:70
  30. The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and...

    Authors: Virginia Ruiz-Martín, Tamara Marcos, José María de Pereda, Mariano Sánchez-Crespo, Miguel Angel de la Fuente, Yolanda Bayón and Andrés Alonso
    Citation: Biological Research 2024 57:69
  31. Müllerian duct anomalies (MDAs) are congenital developmental disorders that present as a series of abnormalities within the reproductive tracts of females. Genetic factors are linked to MDAs and recent advance...

    Authors: Shuya Chen, Yali Fan, Yujun Sun, Shenghui Li, Zhi Zheng, Chunfang Chu, Lin Li and Chenghong Yin
    Citation: Biological Research 2024 57:68
  32. Zebrafish are widely used in various research fields and to fulfil the diverse research needs, numerous zebrafish lines are available, each with a unique domestication background, potentially resulting in intr...

    Authors: Céline Chevalier, Clémence Denis, Sid-Ahmed Nedjar, Yannick Ledoré, Frédéric Silvestre, Bérénice Schaerlinger and Sylvain Milla
    Citation: Biological Research 2024 57:67
  33. Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the advances in understanding SSC biology in mouse models, the mechanisms underlying human SSC...

    Authors: Xueheng Zhao, Lvjun Liu, Zenghui Huang, Fang Zhu, Huan Zhang and Dai Zhou
    Citation: Biological Research 2024 57:66
  34. Increasing evidences demonstrate the role of sensory innervation in bone metabolism, remodeling and repair, however neurovascular coupling in bone is rarely studied. Using microfluidic devices as an indirect c...

    Authors: Alice Leroux, Micaela Roque, Elina Casas, Jacques Leng, Christelle Guibert, Beatrice L’Azou, Hugo Oliveira, Joëlle Amédée and Bruno Paiva dos Santos
    Citation: Biological Research 2024 57:65
  35. Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, ha...

    Authors: Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue and Xiaolong Liu
    Citation: Biological Research 2024 57:64
  36. Chilean peach growers have achieved worldwide recognition for their high-quality fruit products. Among the main factors influencing peach fruit quality, sweetness is pivotal for maintaining the market's compet...

    Authors: Gerardo Núñez-Lillo, Victoria Lillo-Carmona, Alonso G. Pérez-Donoso, Romina Pedreschi, Reinaldo Campos-Vargas and Claudio Meneses
    Citation: Biological Research 2024 57:63
  37. Neisseria gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. There are no vaccines and infections are treated principally with antibiotics. However, gonococci rapidly develop resistance to every...

    Authors: Ravi Kant, Hannah Tilford, Camila S. Freitas, Dayana A. Santos Ferreira, James Ng, Gwennan Rucinski, Joshua Watkins, Ryan Pemberton, Tigran M. Abramyan, Stephanie C. Contreras, Alejandra Vera and Myron Christodoulides
    Citation: Biological Research 2024 57:62
  38. Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine ...

    Authors: Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, Rusong Zhao…
    Citation: Biological Research 2024 57:60
  39. Tumour dormancy, a resistance mechanism employed by cancer cells, is a significant challenge in cancer treatment, contributing to minimal residual disease (MRD) and potential relapse. Despite its clinical impo...

    Authors: Marie-Océane Laguillaumie, Sofia Titah, Aurélie Guillemette, Bernadette Neve, Frederic Leprêtre, Pascaline Ségard, Faruk Azam Shaik, Dominique Collard, Jean-Claude Gerbedoen, Léa Fléchon, Lama Hasan Bou Issa, Audrey Vincent, Martin Figeac, Shéhérazade Sebda, Céline Villenet, Jérôme Kluza…
    Citation: Biological Research 2024 57:59
  40. Adipocytokines play a pivotal role in maintaining adipose tissue homeostasis by regulating cellular metabolism, proliferation, differentiation, and secretory activity. These soluble factors are relevant compon...

    Authors: Thomas M. Sessler, Justus P. Beier, Sophia Villwock, Danny Jonigk, Edgar Dahl and Tim Ruhl
    Citation: Biological Research 2024 57:58
  41. While calcium is known to play a crucial role in mammalian sperm physiology, how it flows in and out of the male gamete is not completely understood. Herein, we investigated the involvement of Na+/Ca2+ exchangers...

    Authors: Marc Yeste, Adeel Ahmad, Estel Viñolas, Sandra Recuero, Sergi Bonet and Elisabeth Pinart
    Citation: Biological Research 2024 57:57
  42. Synaptic dysfunction is an early feature in Alzheimer’s disease (AD) pathogenesis and a major morphological correlate of memory deficits. Given the main synaptic location of N-methyl-D-aspartate receptors (NMDARs...

    Authors: Rocio Alfaro-Ruiz, Alejandro Martín-Belmonte, Carolina Aguado, Ana Esther Moreno-Martínez, Yugo Fukazawa and Rafael Luján
    Citation: Biological Research 2024 57:56
  43. After menstruation the uterine spiral arteries are repaired through angiogenesis. This process is tightly regulated by the paracrine communication between endometrial stromal cells (EnSCs) and endothelial cell...

    Authors: Janet P. Raja Xavier, Toshiyuki Okumura, Melina Apweiler, Nirzari A. Chacko, Yogesh Singh, Sara Y Brucker, Satoru Takeda, Florian Lang and Madhuri S Salker
    Citation: Biological Research 2024 57:55
  44. Brain damage triggers diverse cellular and molecular events, with astrocytes playing a crucial role in activating local neuroprotective and reparative signaling within damaged neuronal circuits. Here, we inves...

    Authors: Lina M. Delgado-García, Ana C. Ojalvo-Sanz, Thabatta K. E. Nakamura, Eduardo Martín-López, Marimelia Porcionatto and Laura Lopez-Mascaraque
    Citation: Biological Research 2024 57:54
  45. As a common disabling disease, irreversible neuronal death due to spinal cord injury (SCI) is the root cause of functional impairment; however, the capacity for neuronal regeneration in the developing spinal c...

    Authors: Zuliyaer Talifu, Chunjia Zhang, Xin Xu, Yunzhu Pan, Han Ke, Zehui Li, Wubo Liu, Huayong Du, Xiaoxin Wang, Feng Gao, Degang Yang, Yingli Jing, Yan Yu, Liangjie Du and Jianjun Li
    Citation: Biological Research 2024 57:53
  46. Common bean (Phaseolus vulgaris) is one of the main nutritional resources in the world, and a low environmental impact source of protein. However, the majority of its cultivation areas are affected by drought and...

    Authors: Vera Martínez-Barradas, Massimo Galbiati, Francisco Barco-Rubio, Dario Paolo, Carmen Espinoza, Eleonora Cominelli and Patricio Arce-Johnson
    Citation: Biological Research 2024 57:52
  47. Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT). This expansi...

    Authors: Consuelo Arias, Javiera Álvarez-Indo, Mariana Cifuentes, Eugenia Morselli, Bredford Kerr and Patricia V. Burgos
    Citation: Biological Research 2024 57:51