Fig. 2

Fmr1 KO mice show impairments in the discrimination of complex odor mixtures. (A) Behavioral responses of the go/no-go task involving the discrimination of two complex odor mixtures: 10 C (CS+) is a mixture of 10 monomolecular odorants diluted in mineral oil, while 10 C-1 (CS-) is composed of 9 of the 10 odorants used for 10 C. Mice who did not reach the criterium on the first day repeated the test the following day. Compared to WT mice, Fmr1 KO shows deficiencies in correctly discriminating 10 C from 10 C-1. (B) AUC-ROC summary of the first and last 60 trials of each session of 10 C vs. 10 C-1 task. (C) Behavioral responses to isoamyl acetate (CS+) vs. mineral oil (CS-), 5 weeks later. Only the mice that previously reached criterium on this task were allowed to perform the test in this instance. Compared to WT mice, Fmr1 KO shows a worse performance in the first blocks of the session, suggesting deficiencies in correctly remembering previously learned olfactory tasks. (D) AUC-ROC summary of the first and last 60 trials of the session. In A, shaded area represents mean ± standard deviation (SD). In B and D, bars represent the standard error (SEM; *p < 0,05, **p < 0,01, ***p < 0,001, ****p < 0,0001)