Fig. 7

S-100-immunoreactivity in cells in the cortical plate at 26 gw, right hemisphere, coronal section: (a) –cells in the cortical plate of the calcarine sulcus (Cas) bank, scale bar: 50 μm; (b) – S-100-immunoreactivity coefficient of the layer I at various gestational ages for calcarine sulcus and parietooccipital sulcus. (c) - S-100-immunoreactivity in neuroblasts in the fundus of the Cas in the deep cortical layers IVc, V, and VI, scale bar: 100 μm. (d) – Scheme of the distribution of S-100-immunoreactive cells in the cortical plate at different stages of fetal development. At 26 gw, S-100-immunoreactive cells are located in deep layers of neuroblasts of the cortical plate in the center of the primary visual field in the calcarine fundus. At 28, 34, and 40 gw, S-100-immunoreactive cells are detected in the gyri, but not in sulci or the border of cytoarchitectonic fields. (e) – S-100-immunoreactivity coefficient at different stages: provisional sulci; the parietooccipital sulcus smothing stage (Pos-); two sulci, when both sulci exist; the calcarine sulcus smoothing stage (Cas-); permanent sulci. (f) – S-100-immunoreactivity coefficient in early fetal (ef), middle fetal (mf) and late fetal (lf) periods. Significant differences between sulci are marked by square brackets and asterisks (*** p < 0.001)