Fig. 5

Effects of OXY administration on exercise performance during normobaric-normoxia (NN) and hypobaric-hypoxia (HH) in rats. (A) A representative cartoon depicts the exercise training test protocol. (B) Before OXY administration, the animal showed similar exercise deterioration during HH compared to the NN. (C) Notably, 14 days of OXY administration promoted a non-impairment of exercise performance during HH, which was observed in the Veh group. (D) OXY achieved to improve the work done during HH (repeated measures ANOVA (2 × 2) followed by Holm-Sidak posthoc. *, p < 0.05; **, p < 0.01; ***, p < 0.001) (n = 6 for each group)