Fig. 9

Tryptophan (Trp) recovered methylglyoxal (MGO) induced depression and memory loss behavior in mice. (A) Schematic diagram of the experimental plan. (B) The percentage of sucrose consumption in the sucrose preference test (SPT). (C) The total distance and time spend in the opened arms from elevated plus maze (EPM) test. (D) The total distance and latency to reach the target in the barnes maze (BM) test for 4 days. The mean latency time to reach the target for 4 days were analyzed. All results obtain from behavior tests was calculated using SMART3.0 SUPER PACK. The values are presented as mean ± SEM (n = 8). ^###p < 0.001 vs. control group (CON). ^**p < 0.01 and ^***p < 0.001 vs. MGO-induced group (MGO). CON, control group. MGO, 65 mg/kg of MGO rectal injection group. MGO + Trp, 65 mg/kg of MGO rectal injection with 40 mg/kg of Trp oral administration group