Fig. 8

Tryptophan (Trp) rescued methylglyoxal (MGO) induced depression and memory dysfunction in mice. (A) Schematic diagram of the experimental plan. (B) The total distance, time spent and speed in the open field test (OFT). (C) The immobility time in the tail suspension test (TST) chamber (D) The immobility time in the forced swim test (FST) chamber. (E) The percentage of recognition index in novel object tool in the novel objective recognition test (NORT). (F) The number of total arm entries and the summary of the percentage of alteration in the Y-maze test. All results obtain from behavior tests was calculated using SMART3.0 SUPER PACK. The values are presented as mean ± SEM (n = 8). ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 vs. control group (CON). ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001 vs. MGO-induced group (MGO). CON, control group. MGO, 65 mg/kg of MGO rectal injection group. MGO + Trp, 65 mg/kg of MGO rectal injection with 40 mg/kg of Trp oral administration group