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Fig. 5 | Biological Research

Fig. 5

From: Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration

Fig. 5

Methylglyoxal (MGO) activated Tau and Akt/GSK-3β phosphorylation and reduced BDNF/TrkB or NGF/TrkB protein expression in mice. (A) The expressed levels of p-Tau, Tau, APP, oAβ, p-Akt, Akt, p-GSK-3β, GSK-3β, and GAPDH by western blotting assay. (B) The expressed levels of BDNF, NGF, PSD95, p-TrkB, TrkB, p-TrkA, TrkA, RAGE, and GAPDH by western blotting assay. The densitometry graph of each band. All data presented as mean ± SEM (n = 3). #p < 0.05 and ##p < 0.01 vs. control group (CON). CON, control group. MGO, 65 mg/kg of MGO rectal injection group

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Biological Research

ISSN: 0717-6287

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