Fig. 7
From: EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
Schematic model of EZH1/2 functioning in oocytes during the first meiotic prophase. (A) At the onset of oocyte meiosis, SPO11-mediated DNA double-strand breaks swiftly recruit and activate elements involved in DNA damage repair, including γ-H2AX, Hormad1, the MRN complex, and ATM kinase. EZH1/2, along with other histone modification factors, directly regulate the activation of these DNA damage repair components through chromatin structural modifications and indirectly mediate the transcription of genes associated with meiosis and oocyte development. (B) Following the inhibition or knockout of EZH1/2, the activation of DNA damage repair elements—including the expression of Hormad1 and the MRN complex, as well as ATM phosphorylation— and the expression of multiple genes was disturbed. Consequently, DNA damage repair was impeded, adversely affecting the progression of meiotic prophase I