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Fig. 5 | Biological Research

Fig. 5

From: Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12

Fig. 5

a Schematic of the experimental design and mating strategy used for the study. b Representative image of fetuses born in the F1 generation in the BNFN and BDFO transient dietary groups. c Graphs showing the correlation between histone methylation and foetal growth parameters. c (i-ii) Correlations of histone enrichment at the (i) Dlk1 and (ii) Grb10 promoters with placental weight. Correlation of histone enrichment at the Dlk1 and Grb10 promoters with (iii, iv) head circumference and (v, iv) crown rump length. Promoter region selected for different histone modification is around the CpG islands in the vicinity of promoter region Dlk1—chromosome number 11-12,025,555 and for Grb10 Chromosome number 12-109452966-109453847

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