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Table 3 Activity of Ng-LdcA-16 against different gonococcal strains with reported resistance to ceftriaxone

From: Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism

Isolate bank number

Ceftriaxone MIC90

µM

(mg/L)

Ng-LdcA-16

MIC50

MIC > 90

MBC50

MBC > 90

AR-0194

0.19

(0.125)

0.78

(0.26)

0.78

(0.26)

0.78

(0.26)

0.78

(0.26)

AR-0166

0.19

(0.125)

1.56

(0.5)

3.125

(1.0)

1.56

(0.5)

1.56

(0.5)

AR-0174

0.19

(0.125)

1.56

(0.5)

1.56

(0.5)

1.56

(0.5)

1.56

(0.5)

AR-0190

0.19

(0.125)

1.56

(0.5)

1.56

(0.5)

1.56

(0.5)

1.56

(0.5)

AR-0173

0.19

(0.125)

0.78

(0.26)

1.56

(0.5)

0.78

(0.26)

1.56

(0.26)

P9-17

0.003–0.006

(0.002–0.004)

 < 1.56

(< 0.5)

3.123–6.25

(1.0–2.0)

0.195–0.39 (0.06–0.13)

0.39

(0.13)

  1. MIC50—first dilution that gives ≥ 50% killing
  2. MIC > 90—first dilution that gives > 90% killing
  3. Reduced susceptibility to ceftriaxone is defined as MIC > 0.03 mg/L (Public Health England) and resistance to ceftriaxone is defined as MIC > 0.125mg/L (EUCAST)
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Biological Research

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