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Fig. 1 | Biological Research

Fig. 1

From: Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism

Fig. 1

Screening of compounds in a standard Minimum Inhibitory Concentration (MIC) assay. Ng-LdcA (n = 74) and Ng-LtgD (n = 84) compounds were diluted and tested at a single concentration of 50 µM in wells containing ~ 105 CFU of N. gonorrhoeae strain P9-17. Controls were bacteria alone, GC broth alone (control in the graphs), GC broth with DMSO (10µL/well) alone, and positive control was bacteria treated with ceftriaxone. DMSO alone has no effect on bacterial growth. Optical density was measured after 24 h incubation. The data are shown as the % reduction in optical density compared to the control bacteria alone. Data are from a representative experiment done twice. The red lines denote the 50% cut offline for selecting compounds for further analyses

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