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Fig. 4 | Biological Research

Fig. 4

From: Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology

Fig. 4

NMDAR immunoparticle density at excitatory synapses on spines and interneurons. (A, B) Quantitative analysis showing mean densities of GluN1 in excitatory synapses in spines (panel A) and interneurons (panel B). A significant reduction in the density of immunoparticles for GluN1 was detected in both compartments located in the stratum lacunosum-moleculare (SLM) of the CA1 field of APP/PS1 mice (n = 3 animals per genotype; Mann-Whitney U test, ****P < 0.0001) compared to age matched wild type. No differences were detected in the stratum radiatum (SR) of the CA1 field. (C, D) Correlation of the number of GluN1 immunoparticles and IMP-cluster area on spines and interneuron dendrites. Scatterplots of the number of immunoparticles for GluN1 versus size of excitatory synapses in both wild type and APP/PS1 mice. In the strata radiatum and lacunosum-moleculare there is a positive linear correlation between immunoparticle number and synaptic size in both genotypes (Pearson’s correlation test)

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Biological Research

ISSN: 0717-6287

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