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Fig. 6 | Biological Research

Fig. 6

From: Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice

Fig. 6

Loss of one or both Ptprd alleles does not induce anxious behavior. (A-C) 3-month-old Ptprd+/+ (PTPRD-WT), Ptprd+/- (PTPRD-HET), and Ptprd-/- (PTPRD-KO) mice were tested in open-field anxiety test. (A) Percentage of the total time that the mice spent in the central zone. (B) Number of times that the animals enter the central zone. (C) Total distance traveled. PTPRD-WT, n = 10; PTPRD-HET, n = 16; PTPRD-KO, n = 11. (D-G) 3-month-old Ptprd+/+, Ptprd+/-, and Ptprd-/- mice were tested in the elevated plus maze test (EPM). (D) Percentage of the total time spent in open arms. (E) Percentage of the total time spent in closed arms. (F) Number of times that the animals enter the open arms. (G) Number of times that the animals enter the closed arms. PTPRD-WT, n = 10; PTPRD-HET, n = 12; PTPRD-KO, n = 11. In all graphs, the error bars denote SEMs

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Biological Research

ISSN: 0717-6287

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