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Fig. 4 | Biological Research

Fig. 4

From: Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice

Fig. 4

Inhibitory synaptic transmission in layer 2/3 of the mPFC is impaired in the Ptprd-/- mice. (A) Representative traces (left) and quantitative analysis (right) of sIPSC activity recorded from layer 2/3 pyramidal neurons in the mPFC in Ptprd+/+ (PTPRD-WT), Ptprd+/- (PTPRD-HET), and Ptprd-/- (PTPRD-KO). PTPRD-WT, n = 5 animals, 9 cells; PTPRD-HET, n = 6 animals, 8 cells; PTPRD-KO, n = 4 animals, 9 cells. *p < 0.05. (B) Representative traces (left) and quantitative analysis (right) of mIPSC activity recorded from layer 2/3 pyramidal neurons in the mPFC in Ptprd+/+ (PTPRD-WT), Ptprd+/- (PTPRD-HET), and Ptprd-/- (PTPRD-KO). PTPRD-WT, n = 4 animals, 9 cells; PTPRD-HET, n = 4 animals, 8 cells; PTPRD-KO, n = 4 animals, 8 cells. *p < 0.05. (C) Evoked IPSC amplitudes as a function of stimulus intensity plotted as input/output curves show an increase in Ptprd-/- compared to Ptprd+/+ and Ptprd+/- mice. Significant changes between Ptprd+/+ and Ptprd-/- groups are as “*”. *p < 0.05, **p < 0.01, and ***p < 0.001. PTPRD-WT, n = 4 animals, 7 cells; PTPRD-HET, n = 5 animals, 9 cells; PTPRD-KO, n = 4 animals, 8 cells. (D) Paired-pulse responses at 10, 30, 70, 100, and 300 ms interstimulus intervals (ISI) are similar between genotyping. PTPRD-WT, n = 4 animals, 6 cells; PTPRD-HET, n = 4 animals, 6 cells; PTPRD-KO, n = 5 animals, 8 cells. (E) Short-term synaptic responses (top) and normalized summary data (bottom) evoked by a burst of 20 stimuli at 10 Hz are also similar between genotyping. PTPRD-WT, n = 4 animals, 7 cells; PTPRD-HET, n = 6 animals, 10 cells; PTPRD-KO, n = 4 animals, 7 cells. (F) Excitatory and inhibitory balances show no significant differences between genotyping. PTPRD-WT, n = 4 animals, 8 cells; PTPRD-HET, n = 4 animals, 10 cells; PTPRD-KO, n = 5 animals, 12 cells. In all graphs, the error bars denote SEMs

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Biological Research

ISSN: 0717-6287

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