Table 4 Summary of Gal-3 and Gal-8 in EMT associated with cancer

Gal-3

Colon cancer cell line

(SW480)

Exogenously added

E-cadherin

N-cadherin, vimentin, Twist

N. D

[150]

HCC cell lines (SMMC 7721, HepG2)

Overexpression, knockdown

E-cadherin

Vimentin

N. D

[182]

HCC cell lines (Huh7, Hep3Bm, HepG2, SK-Hep1)

Overexpression, knockdown

N-cadherin, vimentin, MMP-1

PI3K/AKT/GSK-3β/β-catenin

[175]

Gastrointestinal cancer (AGS and SW-480)

Blockade with LCP

E-cadherin

Vimentin, Snail, Twist, ZEB-1

N. D

[181]

Lung adenocarcinoma cell line (A549)

Exogenous added, blockade with GB117

E-cadherin

N-cadherin, vimentin

N. D

[185]

Oran tongue squamous cell carcinoma cell line (Tca8113)

Overexpression, knockdown

E-cadherin

Vimentin

Wnt/ β -catenin

[149]

Breast cancer cell line (MDA-MB-231)

Knockdown

Vimentin, Slug

E-cadherin

N. D

[187]

Breast cancer (MCF7), colon cancer (HCT116) and prostate cancer (DU145) cell lines

Exogenous added, blockade with lactose

E-cadherin

ZEB1

Trop2/β –catenin

[186]

Breast cancer cell line (GI-LM2)

Knockdown

E-cadherin

Vimentin

Inhibition of Wnt and AKT pathways

[151]

Gal-4

Prostate cancer cell lines (PC-3, 22Rv1, LNCaP and DU-145) and mice

Knockdown, blockade with lactose

E-cadherin

Fibronectin, vimentin, Twist

ERK, AKT

[152]

Gal-8

MDCK cell line

Overexpression,

blockade with lactose

E-cadherin

Vimentin, Snail, fibronectin, α5 Integrin, MMP-13

FAK/EGFR/ERK

[153]

Primary prostate cancer cell line

Knockdown

E-cadherin

N. D

N. D

[189]